Photo of Patrick Drew

Patrick Drew

Associate Professor

Affiliation(s):

  • Engineering Science and Mechanics
  • Biomedical Engineering

W317 Millennium Science Complex

pjd17@psu.edu

814-863-1473

Personal or Departmental Website

Research Areas:

Brain Science and Neural Engineering

Interest Areas:

Neuroscience, neurovascular coupling.

 
 

 

Education

  • BS, Biology, California Institute of Technology, 1999
  • Ph D, Neuroscience, Brandeis University, 2004

Publications

Book, Chapters

  • A Shih, P Drew and D Kleinfeld, 2014, Imaging vasodynamics in the awake mouse brain with two-photon microscopy, Springer Science + Business Media, NY, pp. 55-73
  • J Driscoll, A Shih, Patrick Drew, I Valmianski, G Cauwenberg ands, D , 2011, Two-photon imaging of blood flow in rat cortex., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 927-938

Journal Articles

  • Matthew Adams, A T Winder, P Blinder and Patrick Drew, 2018, "The pial vasculature of the mouse develops according to a sensory-independent program.", Scientific reports, 8, (1), pp. 9860
  • Y R Gao, Yanyuan Ma, Qiming Zhang, A T Winder, Z Liang, L Antinori, Patrick Drew and Nanyin Zhang, 2017, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.", NeuroImage, 153, pp. 382-398
  • Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek G Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, Jose A. Stoute, Vernon M Chinchilli, Andrew F Read, Bruce Gluckman and Steven Schiff, 2017, "A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection", SCIENTIFIC REPORTS, 7
  • Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick Drew and Nanyin Zhang, 2017, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal", NEUROIMAGE, 153, pp. 382-398
  • Aaron T. Winder, Christina Echagarruga, Qingguang Zhang and Patrick Drew, 2017, "Weak correlations between hemodynamic signals and ongoing neural activity during the resting state", NATURE NEUROSCIENCE, 20, (12), pp. 1761-+
  • Y R Gao and Patrick Drew, 2016, "Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, (8), pp. 2503-16
  • Y R Gao, S E Greene and Patrick Drew, 2015, "Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.", NeuroImage, 115, pp. 162-76
  • M J Shirey, J B Smith, S E Greene, B X Huo and Patrick Drew, 2015, "Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature.", Journal of neurophysiology, 114, (1), pp. 309-22
  • B X Huo, S E Greene and Patrick Drew, 2015, "Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes.", NeuroImage, 118, pp. 301-312
  • A Y Shih, C Rühlmann, P Blinder, A Devor, Patrick Drew, B Friedman, P M Knutsen, P D Lyden, C Matéo, L Mellander, N Nishimura, C B Schaffer, P S Tsai and D Kleinfeld, 2015, "Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.", Microcirculation (New York, N.Y. : 1994), 22, (3), pp. 204-18
  • Bing-Xing Huo, Yu-Rong Gao and Patrick Drew, 2015, "Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion.", 105, pp. 369-79
  • A Letourneur, V Chen, G Waterman and Patrick Drew, 2014, "A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice", Physiological Reports, 2, (12), pp. 10
  • yu-Rong Gao and Patrick Drew, 2014, "Determination of vessel cross-sectional area by thresholding in Radon space."
  • Bing-Xing Huo, Jared B Smith and Patrick Drew, 2014, "Neurovascular Coupling and Decoupling in the Cortex during Voluntary Locomotion.", Journal of Neuroscience, 34, (33), pp. 10975-81
  • Patrick Drew and Y Gao, 2014, "Automated measurement of vessel cross-sectional area in by thresholding in Radon space", Journal of Cerebral Blood Flow and Metabolism, 34, pp. 1180-1187
  • Jonathan D Driscoll, Andy Y Shih, Patrick Drew, Gert Cauwenberghs and David Kleinfeld, 2013, "Two-photon imaging of blood flow in the rat cortex.", 8, pp. 759-67
  • Andy Y Shih, Celine Mateo, Patrick Drew, Philbert S Tsai and David Kleinfeld, 2012, "A polished and reinforced thinned-skull window for long-term imaging of the mouse brain."
  • A Y Shih, J D Driscoll, P J Drew, N Nishimura, C B Schaffer and D Kleinfeld, 2012, "Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain", J Cereb Blood Flow Metab, 32, (7), pp. 277-309
  • David Kleinfeld, Pablo Blinder, Patrick Drew, Jonathan D Driscoll, Arnaud Muller, Philbert S Tsai and Andy Y Shih, 2011, "A guide to delineate the logic of neurovascular signaling in the brain.", 3, (1)
  • Patrick Drew, Andy Y Shih and David Kleinfeld, 2011, "Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity.", 108, (20), pp. 8473-8478
  • Patrick Drew, Andy Y Shih, Jonathan D Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S Tsai and David Kleinfeld, 2010, "Chronic optical access through a polished and reinforced thinned skull.", 7, (12), pp. 981-984
  • Patrick Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y Shih and David Kleinfeld, 2010, "Rapid determination of particle velocity from space-time images using the Radon transform.", 29, (1-2), pp. 5-11
  • Andy Y Shih, Beth Friedman, Patrick Drew, Philbert S Tsai, Patrick D Lyden and David Kleinfeld, 2009, "Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke.", 29, (4), pp. 738-51
  • Philbert S Tsai, John P Kaufhold, Pablo Blinder, Beth Friedman, Patrick Drew, Harvey J Karten, Patrick D Lyden and David Kleinfeld, 2009, "Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels.", 29, (46), pp. 14553-70
  • Lu Li, Kevin J Bender, Patrick Drew, Shantanu P Jadhav, Emily Sylwestrak and Daniel E Feldman, 2009, "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex.", 64, (4)
  • Patrick Drew and Daniel E Feldman, 2009, "Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex.", 19, (2), pp. 331-48
  • Patrick Drew, Jeff H Duyn, Eugene Golanov and David Kleinfeld, 2008, "Finding coherence in spontaneous oscillations.", 11, (9)
  • Jason Wolfe, Dan N Hill, Sohrab Pahlavan, Patrick Drew, David Kleinfeld and Daniel E Feldman, 2008, "Texture coding in the rat whisker system: slip-stick versus differential resonance."
  • Patrick Drew and Daniel E Feldman, 2007, "Representation of moving wavefronts of whisker deflection in rat somatosensory cortex.", 98, (3), pp. 1566-80
  • P J Drew and L F Abbott, 2006, "Extending the effects of spike-timing-dependent plasticity to behavioral timescales", 103, (23), pp. 8876-81
  • P J Drew and L F Abbott, 2006, "Models and properties of power-law adaptation in neural systems", 96, (2), pp. 826-81
  • S Fusi, P J Drew and LF Abbott, 2005, "Cascade models of synaptically stored memories", 45, (2), pp. 2697-706
  • P J Drew and L F Abbott, 2003, "Model of song selectivity and sequence generation in area HVc of the songbird", 89, (5)
  • Patrick Drew, R Sayres, K Watanabe and S Shimojo, 2001, "Pupillary response to chromatic flicker", (136)

Conference Proceedings

  • Kurt W. Short, Ephraim W. Church, Akshal S. Patel, Kevin M. Cockroft and Patrick Drew, 2016, "Absence of Cortical Microvessel Spasm During Large Vessel Spasm Following Experimental Subarachnoid Hemorrhage", STROKE, 47

Abstracts

  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Noradrenergic modulation of neurovascular coupling in awake behaving mice"
  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Neuronal and non-neuronal factors mediate behavioral-state dependent development of functional hyperemia in the somatosensory cortex of juvenile mice"
  • Priankshesh Patki, Bruce Gluckman, Francesco Costanzo and Patrick Drew, 2017, "Mixture theory based analysis of the glymphatic system"

Research Projects

  • September 2017 - August 2022, "A multimodal approach to understanding the development of neurovascular coupling," (Sponsor: NIH).
  • September 2017 - June 2022, "A multimodal approach to understanding the development of neurovascular coupling," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • September 2017 - June 2022, "A multimodal approach to understanding the development of neurovascular coupling," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • August 2018 - July 2021, "Anatomical basis for ISF and CSF transport through the cribriform plate (Jordan Nicole Norwood)," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • July 2017 - July 2021, "Mechanistic dissection of the neural basis of the resting-state fMRI signal using multi-modal approaches," (Sponsor: National Institute of Mental Health).
  • July 2017 - July 2021, "Mechanistic dissection of the neural basis of the resting-state fMRI signal using multi-modal approaches," (Sponsor: National Institute of Mental Health).
  • September 2017 - August 2020, "Imaging and Modeling Fluid Mechanics of Metabolite Transport in the Brain Interstitium," (Sponsor: National Science Foundation).
  • September 2015 - May 2019, "CRCNS:US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?," (Sponsor: National Institute of Biomedical Imaging and Bioengineering).
  • September 2015 - May 2019, "CRCNS:US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?," (Sponsor: National Institute of Biomedical Imaging and Bioengineering).
  • September 2015 - May 2019, "CRCNS:US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?," (Sponsor: National Institute of Biomedical Imaging and Bioengineering).
  • September 2015 - May 2019, "CRCNS:US-French Research Proposal: Neurovascular coupling-democracy or oligarchy?," (Sponsor: National Institute of Biomedical Imaging and Bioengineering).
  • May 2012 - April 2018, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the behaving mouse," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the behaving mouse," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the behaving mouse," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging Neurovascular Coupling and Functional Connectivity in the Behaving Mouse," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the behaving mouse," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • March 2013 - January 2018, "Imaging neurovascular coupling and functional connectivity in the awake behaving brain," (Sponsor: NIH).
  • August 2012 - July 2017, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: NIH).
  • July 2012 - June 2017, "Imaging Neurovascular Coupling in the Behaving Animal," (Sponsor: McKnight Endowment Fund for Neuroscience).
  • May 2012 - April 2017, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • May 2012 - April 2017, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • May 2012 - April 2017, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • May 2012 - April 2017, "Neurovascular coupling during spontaneous and sensory evoked activity," (Sponsor: National Institute of Neurological Disorders and Stroke).
  • February 2015 - January 2016, "Craniosynostosis Network," (Sponsor: Icahn School of Medicine at Mount Sinai).
  • January 2012 - December 2016, "The Roles of Flow and Neural Activity in the Development of the Cerebral Vasculature (Scientist Development Grant)," (Sponsor: American Heart Association (AHA)).
  • September 2012 - August 2015, "A Murine Model for Preventing Postmalarial Epilepsy," (Sponsor: Citizens United for Research in Epilepsy).
  • January 2012 - December 2015, "The roles of flow and neural activity in the development of the cerebral vasculature," (Sponsor: American Heart Association).
  • September 2012 - August 2015, "A murine model for preventing postmalarial epilepsy," (Sponsor: Citizens United for Research in Epilepsy (CURE)).
  • July 2012 - June 2015, "Imaging neurovascular coupling during behavior," (Sponsor: McKnight Foundation Scholar Award).

Honors and Awards

  • Huck Distinguished Associate Professorship, Huck Institute, July 2017 - June 2020

Service

Service to Penn State:

  • Committee Work, Committee Member, Interdepartmental Graduate Program in Bioengineering Advisory Committee, January 2017
  • Contribution to Programs to Enhance Equal Opportunity/Cultural Diversity, June 2016
  • Committee Work, Bioengineering Graduate program admissions committee, June 2015
  • Committee Work, Admissions committee, Molecular, Cellular and Integrative Biosciences, Admissions committee, Molecular, Cellular and Integrative Biosciences, November 2015
  • Committee Work, Moderator, Senior Thesis Proposal, January 2014 - January 2016
  • Other, CoE REU Proposals, Reviewer, 2014 - 2014
  • Committee Work, Other, Elected Representative, Graduate Council, September 2014 - June 2016
  • Faculty Advisor, PSU Neuroscience Student Society, September 2013 - September 2015
  • Committee Work, Member, Neuroscience Graduate Curriculum Committee, July 2013
  • Committee Work, Member, MD/PhD Steering Committee, March 2013
  • Committee Work, Member, Center for Molecular Investigation of Neurological Disorders, May 2013
  • Committee Work, Committee Member, ESM Undergraduate Curriculum Committee, October 2012
  • Committee Work, Member, ESM Undergraduate Curriculum Committee, October 2012
  • Other, on-going research collaboration with Dr. Kevin Cockroft on imaging the effects of vasospasm on the cerebral microvasculature, Department of Neurosurgery, Milton S. Hershey College of Medicine, September 2011
  • Committee Work, Other, Joint Appointment, Department of Neurosurgery, Milton S. Hershey College of Medicine, June 2010
  • Committee Work, Member, Neural Engineering candidacy exam committee, September 2010
  • Committee Work, Member, MD/PhD Program Committee, September 2010
  • Committee Work, Member, Joint MD-PHD in Engineering Science and Mechanics Committee, December 2010
  • Committee Work, Member, Center for Neural Engineering, January 2010
  • Committee Work, Member, Huck Institute for Life Sciences, January 2010
  • Committee Work, Member, Materials Research Institute, January 2010
  • Committee Work, Member, Penn State Institute for Neuroscience, January 2010
  • Director of Optical Imaging for the Social, Life and Engineering, January 2010 - 2015
  • Assistance to Student Organizations, Advisor, Schreyer Honors College, September 2010
  • Joint appointment with the Department of Neurosurgery, Milton S. Hershey College of Medicine, June 2010
  • Hosted lab experience for high school students thorough the ScienceU program, July 2016
  • Contribution to Programs to Enhance Equal Opportunity/Cultural Diversity, Invited panelist MRSEC “Women in STEM” mixer, March 2014

Service to External Organizations:

  • Organizing Conferences and Service on Conference Committees, Co-Organizer, program committee, Optics and the Brain, April 2016 - April 2016
  • Organizing Conferences and Service on Conference Committees, Reviewer, Reviewer for Computational and Systems Neurosceince Conference, December 2016
  • Other, Co-Moderator, Brain equations: challenges and next generation mathematical models, April 2015
  • Organizing Conferences and Service on Conference Committees, Workshop leader, Focus Program on Neurovascular Coupling And Related Phenomena, July 2014
 


 

About

The Penn State Department of Engineering Science and Mechanics (ESM) is an internationally distinguished department that is recognized for its globally competitive excellence in engineering and scientific accomplishments, research, and educational leadership.

Our Engineering Science program is the official undergraduate honors program of the College of Engineering, attracting the University’s brightest engineering students. We also offer graduate degrees in ESM, engineering mechanics, engineering at the nano-scale, and an integrated undergraduate/graduate program.

Department of Engineering Science and Mechanics

212 Earth and Engineering Sciences Building

The Pennsylvania State University

University Park, PA 16802

Phone: 814-865-4523