Photo of Patrick Drew

Patrick Drew



  • Engineering Science and Mechanics
  • Biomedical Engineering

W317 Millennium Science Complex


Personal or Departmental Website

Research Areas:

Brain Science and Neural Engineering

Interest Areas:

Neuroscience, neurovascular coupling.




  • BS, Biology, California Institute of Technology, 1999
  • Ph D, Neuroscience, Brandeis University, 2004


Journal Articles

  • Patrick Drew, 2022, "Neurovascular coupling: motive unknown", Trends in Neurosciences, 45, (11), pp. 809-819
  • Qingguang Zhang, K W Gheres and Patrick Drew, 2021, "Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.", PLoS biology, 19, (7), pp. e3001298
  • A K Aydin, W D Haselden, J Dang, Patrick Drew, S Charpak and D Boido, 2021, "Iliski, a software for robust calculation of transfer functions.", PLoS computational biology, 17, (6), pp. e1008614
  • A Das, K Murphy and Patrick Drew, 2021, "Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow.", Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 376, (1815), pp. 20190635
  • K L Turner, K W Gheres, Elizabeth Anne Proctor and Patrick Drew, 2020, "Neurovascular coupling and bilateral connectivity during NREM and REM sleep.", eLife, 9
  • C T Echagarruga, K W Gheres, J N Norwood and Patrick Drew, 2020, "nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice.", eLife, 9
  • Patrick Drew, C Mateo, K L Turner, X Yu and D Kleinfeld, 2020, "Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds.", Neuron, 107, (5), pp. 782-804
  • R T Kedarasetti, K L Turner, C Echagarruga, Bruce Gluckman, Patrick Drew and Francesco Costanzo, 2020, "Functional hyperemia drives fluid exchange in the paravascular space.", Fluids and barriers of the CNS, 17, (1), pp. 52
  • W D Haselden, R T Kedarasetti and Patrick Drew, 2020, "Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.", PLoS computational biology, 16, (7), pp. e1008069
  • R T Kedarasetti, Patrick Drew and Francesco Costanzo, 2020, "Arterial pulsations drive oscillatory flow of CSF but not directional pumping.", Scientific reports, 10, (1), pp. 10102
  • A K Aydin, W D Haselden, Y Goulam Houssen, C Pouzat, R L Rungta, C Demené, M Tanter, Patrick Drew, S Charpak and D Boido, 2020, "Transfer functions linking neural calcium to single voxel functional ultrasound signal.", Nature communications, 11, (1), pp. 2954
  • Q Zhang, M Roche, K W Gheres, E Chaigneau, R T Kedarasetti, W D Haselden, S Charpak and Patrick Drew, 2019, "Cerebral oxygenation during locomotion is modulated by respiration.", Nature communications, 10, (1), pp. 5515
  • Patrick Drew, A T Winder and Qiming Zhang, 2019, "Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.", The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 25, (4), pp. 298-313
  • Patrick Drew, 2019, "Vascular and neural basis of the BOLD signal.", Current opinion in neurobiology, 58, pp. 61-69
  • J N Norwood, Q Zhang, D Card, A Craine, Timothy M Ryan and Patrick Drew, 2019, "Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate.", eLife
  • Matthew Adams, A T Winder, P Blinder and Patrick Drew, 2018, "The pial vasculature of the mouse develops according to a sensory-independent program.", Scientific reports, 8, (1), pp. 9860
  • Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek G Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, Jose A. Stoute, Vernon M. Chinchilli, Andrew F Read, Bruce Gluckman and Steven Schiff, 2017, "A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection", SCIENTIFIC REPORTS, 7
  • Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick Drew and Nanyin Zhang, 2017, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal", NEUROIMAGE, 153, pp. 382-398
  • Aaron T. Winder, Christina Echagarruga, Qingguang Zhang and Patrick Drew, 2017, "Weak correlations between hemodynamic signals and ongoing neural activity during the resting state", Nature Neuroscience, 20, (12), pp. 1761-1769
  • Y R Gao and Patrick Drew, 2016, "Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, (8), pp. 2503-16
  • B X Huo, S E Greene and Patrick Drew, 2015, "Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes.", NeuroImage, 118, pp. 301-12
  • Y R Gao, S E Greene and Patrick Drew, 2015, "Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.", NeuroImage, 115, pp. 162-76
  • M J Shirey, J B Smith, S E Greene, B X Huo and Patrick Drew, 2015, "Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature.", Journal of neurophysiology, 114, (1), pp. 309-22
  • A Y Shih, C Rühlmann, P Blinder, A Devor, Patrick Drew, B Friedman, P M Knutsen, P D Lyden, C Matéo, L Mellander, N Nishimura, C B Schaffer, P S Tsai and D Kleinfeld, 2015, "Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.", Microcirculation (New York, N.Y. : 1994), 22, (3), pp. 204-18
  • Bing-Xing Huo, Yu-Rong Gao and Patrick Drew, 2015, "Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion.", NeuroImage, 105, pp. 369-79
  • A Letourneur, V Chen, G Waterman and Patrick Drew, 2014, "A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice", Physiological Reports, 2, (12), pp. 10
  • Yu-Rong Gao and Patrick Drew, 2014, "Determination of vessel cross-sectional area by thresholding in Radon space.", Journal of Cerebral Blood Flow and Metabolism, 34, pp. 1180-1187
  • Bing-Xing Huo, Jared B Smith and Patrick Drew, 2014, "Neurovascular Coupling and Decoupling in the Cortex during Voluntary Locomotion.", Journal of Neuroscience, 34, (33), pp. 10975-81
  • Jonathan D Driscoll, Andy Y Shih, Patrick Drew, Gert Cauwenberghs and David Kleinfeld, 2013, "Two-photon imaging of blood flow in the rat cortex.", Cold Spring Harb Protoc, 8, pp. 759-67
  • Andy Y Shih, Celine Mateo, Patrick Drew, Philbert S Tsai and David Kleinfeld, 2012, "A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.", JoVE, 61
  • A Y Shih, J D Driscoll, P J Drew, N Nishimura, C B Schaffer and D Kleinfeld, 2012, "Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain", J Cereb Blood Flow Metab, 32, (7), pp. 277-309
  • David Kleinfeld, Pablo Blinder, Patrick Drew, Jonathan D Driscoll, Arnaud Muller, Philbert S Tsai and Andy Y Shih, 2011, "A guide to delineate the logic of neurovascular signaling in the brain.", Frontiers in Neuroenergetics, 3, (1), pp. 9
  • Patrick Drew, Andy Y Shih and David Kleinfeld, 2011, "Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity.", Proceedings of the National Acadamy of Sciences, 108, (20), pp. 8473-8478
  • Patrick Drew, Andy Y Shih, Jonathan D Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S Tsai and David Kleinfeld, 2010, "Chronic optical access through a polished and reinforced thinned skull.", Nature Methods, 7, (12), pp. 981-984
  • Patrick Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y Shih and David Kleinfeld, 2010, "Rapid determination of particle velocity from space-time images using the Radon transform.", Journal of Computational Neuroscience, 29, (1-2), pp. 5-11
  • Andy Y Shih, Beth Friedman, Patrick Drew, Philbert S Tsai, Patrick D Lyden and David Kleinfeld, 2009, "Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke.", Journal of Cerebral Blood Flow and Metabolism, 29, (4), pp. 738-51
  • Philbert S Tsai, John P Kaufhold, Pablo Blinder, Beth Friedman, Patrick Drew, Harvey J Karten, Patrick D Lyden and David Kleinfeld, 2009, "Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels.", Journal of Neuroscience, 29, (46), pp. 14553-70
  • Lu Li, Kevin J Bender, Patrick Drew, Shantanu P Jadhav, Emily Sylwestrak and Daniel E Feldman, 2009, "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex.", Neuron, 64, (4)
  • Patrick Drew and Daniel E Feldman, 2009, "Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex.", Cerebral Cortex, 19, (2), pp. 331-48
  • Patrick Drew, Jeff H Duyn, Eugene Golanov and David Kleinfeld, 2008, "Finding coherence in spontaneous oscillations.", Nature Neuroscience, 11, (9)
  • Jason Wolfe, Dan N Hill, Sohrab Pahlavan, Patrick Drew, David Kleinfeld and Daniel E Feldman, 2008, "Texture coding in the rat whisker system: slip-stick versus differential resonance.", PLOS Biology, 6, (8), pp. e215
  • Patrick Drew and Daniel E Feldman, 2007, "Representation of moving wavefronts of whisker deflection in rat somatosensory cortex.", Journal of Neurophysiology, 98, (3), pp. 1566-80
  • P J Drew and L F Abbott, 2006, "Extending the effects of spike-timing-dependent plasticity to behavioral timescales", Proceedings of the National Acadamy of Sciences, 103, (23), pp. 8876-81
  • P J Drew and L F Abbott, 2006, "Models and properties of power-law adaptation in neural systems", Journal of Neurophysiology, 96, (2), pp. 826-81
  • S Fusi, P J Drew and LF Abbott, 2005, "Cascade models of synaptically stored memories", Neuron, 45, (2), pp. 2697-706
  • P J Drew and L F Abbott, 2003, "Model of song selectivity and sequence generation in area HVc of the songbird", Joournal of Neurophysiology, 89, (5), pp. 2697-2706
  • Patrick Drew, R Sayres, K Watanabe and S Shimojo, 2001, "Pupillary response to chromatic flicker", Experimental Brain Research, (136), pp. 256-62
  • Qingguang Zhang, Kevin Turner, Kyle Gheres, Md Shakhawat Hossain and Patrick Drew, , ": Behavioral and physiological monitoring for awake neurovascular coupling experiments: A how-to guide"

Conference Proceedings

  • Kurt W. Short, Ephraim W. Church, Akshal S. Patel, Kevin M. Cockroft and Patrick Drew, 2016, "Absence of Cortical Microvessel Spasm During Large Vessel Spasm Following Experimental Subarachnoid Hemorrhage", STROKE, 47


  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Noradrenergic modulation of neurovascular coupling in awake behaving mice"
  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Neuronal and non-neuronal factors mediate behavioral-state dependent development of functional hyperemia in the somatosensory cortex of juvenile mice"
  • Priankshesh Patki, Bruce Gluckman, Francesco Costanzo and Patrick Drew, 2017, "Mixture theory based analysis of the glymphatic system"


  • Yuan-Ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Muñoz-Castañeda, Keith C Cheng, Pavel Osten, Patrick Drew and Yongsoo Kim, , "The cellular architecture of microvessels, pericytes and neuronal cell types in organizing regional brain energy homeostasis in mice"

Research Projects

Honors and Awards


Service to Penn State:

Service to External Organizations:




The Penn State Department of Engineering Science and Mechanics (ESM) is an internationally distinguished department that is recognized for its globally competitive excellence in engineering and scientific accomplishments, research, and educational leadership.

Our Engineering Science program is the official undergraduate honors program of the College of Engineering, attracting the University’s brightest engineering students. We also offer graduate degrees in ESM, engineering mechanics, engineering at the nano-scale, and an integrated undergraduate/graduate program.

Department of Engineering Science and Mechanics

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The Pennsylvania State University

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Phone: 814-865-4523