Steven J. Schiff


Steven J. Schiff, MD, PhD
Director, Penn State Center for Neural Engineering
Brush Chair Professor of Engineering
Professor of Neurosurgery
Professor of Engineering Science and Mechanics
Professor of Physics (Courtesy Appointment)

W311 Millennium Science Complex
Pollock Road
University Park, PA 16802-2131
(814) 865-2481 Shari Walczak (Center Administration) slw2 at engr.psu.edu
(814) 863-4210 Office
(815) 550-2150 Fax
Send E-Mail sschiff at psu.edu

http://www.esm.psu.edu/schiff

Google Scholar Citations


New Paper: Wei Y,Ullah G, Schiff SJ. Unification of Neuronal Spikes, Seizures, and Spreading Depression. Journal of Neuroscience, 34:11733-11743, 2014.

A Code Archive for this paper is available here.
Video of recent Fields Institute Lecture describing these results.
Video of recent talk at Festschrift for Jack Cowan at Banff International Research Station.


My book was published in 2012: Neural Control Engineering, The MIT Press


Physics Today Book Review December 2012 by Jack Cowan
Amazon Reviews Amazon Amazon Kindle Edition
MIT Press MIT Press eBook A Matlab Book:The Mathworks Google Books Preview
Errata Lecture Slides Code Archive


House Foreign Relations Subcommittee on Africa, Global Health, and Human Rights hearings August 2, 2011
Hearing Book Congressional Hearing Book with Testimony on Hydrocephalus from the Congressional Record at the US Government Printing Office.
CSPAN Coverage of Hydrocephalus Hearings August 2, 2011CSPAN Coverage of Hydrocephalus Hearings August 2, 2011


See 2013 article at United Nations Earth News UNEarthNews UN Earth News
See 2013 article and radio piece at Voice of America Voice of America
See 2012 article in (Spanish or Catalan) “Nuestro cerebro también piensa sin palabras”La Vanguardia or La Vanguardia
The route to Africa and the Viola in Penn State News
See Spring 2010 article in Penn State Research Magazine
See Fall 2010 article in Engineering Penn State Magazine
See June 2008 article at Technology Review


Recent covers:
mandell_et_al_dynamics_brain_csf_fluid_growth_j_neurosurgery_2010_cover.jpg article li_et_al_association_of_bacteria_with_hydrocephalus_in_ugandan_infants_j_neurosurg_peds_2011_cover.jpg articlearticle


Research Interests:

I am a Pediatric Neurosurgeon, with particular interests in understanding the physics of dynamical disease of the nervous system, developing smart prosthetics to treat those diseases, and an interest in global health.

Dynamical Diseases are where the predominant symptomatology manifests as disordered interaction between the elements of the organ in question. My focus is on the nervous system, and grew out of my experience in treating Epilepsy as well as the Spasticity of Cerebral Palsy. Our best surgical treatment offerings for such diseases involves destructive resection, and my goals for many years have centered around the science and engineering of alternatives to such therapies.

Finding better treatments to such dynamical disease requires that we understand the underlying physical principles that govern the normal, and disordered, interactions between elements of the nervous system. I have spent considerable time focusing on the cellular interactions that make up pattern formation in seizures, Parkinson’s disease, and the origin of migraines (spreading depression). I am also deeply involved in learning how to use electrical stimulation to alter such interactions, so that we can design intelligent control algorithms. In human EEG, I have done fundamental work on the signal processing of seizures, discrimination analysis, real time modulation of stimulation based on EEG, and robotic brain-machine interfaces for assistive devices.

An area of special focus of mine is in developing the interdisciplinary fusion of Neural Control Engineering. I recently wrote a book, published by the MIT Press, exploring this intersection between control engineering and dynamical disease of the brain in much detail.

Lastly, with support from a Grace Woodward Grant for Collaborative Research in Engineering and Medicine, and a Clinical Translational Science Institute award, I have begun a number of projects to work on improving the diagnosis and treatment of neurosurgical diseases in East Africa. Improving medical care with the constraints of limited resources, through better engineering and image analysis, is a goal that is of broad utility in both the developing and industrialized countries. Furthermore, the under-recognized impact of infectious diseases on creating diseases of the nervous system that we have treated neurosurgically, such as hydrocephalus and epilepsy, is one that I am devoting increasing effort to.


Penn State Center for Neural Engineering

The Penn State Center for Neural Engineering, an intercollege center bridging the Colleges of Engineering, Medicine and Science, was Chartered in June, 2007. With Professor Bruce J. Gluckman as the Associate Director, the Center occupies 22,000 square feet of space in the new Millennium Sciences Complex, a structure which brings together faculty and laboratories from Materials Science and Life Sciences at Penn State.

With the help of a P30 Research Core Center Grant from NIH in 2009-2010, “Innovations at the Intersection of Neural Engineering, Materials Sci & Medicine”, we have continued to grow and recruit outstanding faculty to the Center. Our present complement in the new facility includes:


Schiff lab People.


US Patents

  • 5,522,863 Pulsating behavior monitoring and modification system for neural networks
  • 5,797,965 Suppression of epileptiform activity
  • 5,800,459 Electric field control of epiletiform activity
  • 6,873,872 Adaptive electric field modulation of neural systems (methods)
  • 6,665,562 Adaptive electric field modulation of neural systems (device)
  • 8,718,755 Methods and Devices for Determining Brain State

And the latest model-based control patent:

  • 8,588,899 Model based control of Parkinson's disease

Teaching and Curricula:

New Course Fall 2008, 2009, 2011: Neural Control Engineering

New Course Spring 2009, 2012: Neuroethics and Neurolaw

New Neural Engineering PhD Track in Engineering Sciences and Mechanics

New MD-PhD Track in Engineering Sciences and Mechanics


Conferences:

Implanting Change: The Ethics of Neural Prosthetics 2007

International Workshop on Seizure Prediction, 2011

Mathematical Biosciences Institute Neuroscience Year 2012-2013


Publications:

Scientific Articles Published in Refereed Journals | Invited Contributions and Reviews

Education & Training:

  • SB, MIT, 1977
  • MD, Duke University, 1980
  • PhD (Physiology, G. Somjen), Duke University, 1985
  • General Surgery Internship, Duke University, 1981
  • Neurosurgery Residency, Duke University, 1989
  • Pediatric Neurosurgery Fellowship, Children's Hospital of Philadelphia, 1990


Certification:

  • Diplomat of the American Board of Neurological Surgery, 1992


Editorial Boards:

  • Journal of Computational Neuroscience, Action Editor, 2006-
  • Physical Review X, Editorial Board, 2012-, Physical Review Letters, Divisional Associate Editor, 2006-2012, Physical Review E, Editorial Board 2000-2005.
  • Journal of Neural Engineering, Editorial Board, 2013-


Recent Funding:


Misc:

  • Fellow of the American College of Surgeons (FACS), 1994
  • Independent Scientist Awards, National Institutes of Health, 1997, 2003
  • Listed in 'Guide to America's Top Physicians', 2nd Edition, 2005, published by the Consumers' Research Council of America.
  • Listed in 'Guide to America's Top Surgeons', 3rd Edition, 2006, published by the Consumers' Research Council of America.
  • Fellow of the American Physical Society, 2005
    • Citation: “For his contributions to the physical and biological understanding and control of the dynamics of neural signals in the brain.
  • Fellow of the American Association of Neurological Surgeons (FAANS), 2010
  • Listed in 'Guide to America's Top Surgeons', 8th Edition, 2011, published by the Consumers' Research Council of America.
  • Fellow of the The American Association for the Advancement of Science, 2012
    • Citation: ”For distinguished contributions to the interface of neuroscience, physics, engineering, and medicine, and in particular the applications of control engineering to dynamical diseases of the brain.

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