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Xiaoyun (Sean) Ding
Ph.D. Candidate

Biomedical Nano-Electro-Mechanical-Systems (BioNEMS) Laboratory
Department of Engineering Science and Mechanics
The Pennsylvania State University
N-328 Millennium Science Complex
University Park, PA 16802, USA

+1-814-321-7948 | xding[AT]psu.edu

Aug. 2009 - Current
The Pennsylvania State University, United States.
Ph.D. in Engineering Science and Mechanics
Advisor: Prof. Tony Jun Huang

Sep. 2006 - Jul. 2009
Chinese Academy of Sciences, Shanghai, China.
M. Eng in Microelectronics Engineering.
Advisor: Prof. Le Luo

Sep. 2002 - Jul. 2006
Fudan University, China.
B. Sci. in Material Physics.

Xiaoyun Ding, et al., PNAS, Vol. 109, pp. 11105-11109, 2012. (was reported and highlighted by National Science FoundationNational Institutes of Health Live Science Big Ten Science Lab Spaces One News Page gantdaily MSNBC R&D Medical News Today Nanowerk Science Daily Popular Science Online Journal Newswise domain-b Bio-Medicine Penn State Live Penn State Science Real Clear Science Sci Tech Update Phys Org UPI.com Softpedia ALN Magazine SciTechDaily Futurity DVICE Inside Science )
We have developed the first acoustic manipulation platform, so-called “acoustic tweezers”, which can trap and dexterously manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans) along a programmed route in two-dimensions within a dime-sized microfluidic chip. Fig. 1 A shows the real photo of our acoustic tweezers device. The acoustic tweezers can move a 10-µm single polystyrene bead to write the word “PNAS” (fig.1 B) and a bovine red blood cell to trace the letters “PSU” (fig. 1 C). It was also the first technology capable of touchless trapping and manipulating Caenorhabditis elegans, a one-millimeter long roundworm that is an important model system for studying diseases and development in humans.With its advantages in non-invasiveness, miniaturization, and versatility, our acoustic tweezers will become a powerful tool for many disciplines of science and engineering.

[Xiaoyun Ding, et al., Lab on a Chip, Vol. 12, pp. 2491-2497, 2012. (featured as back cover image) ]

The ordered arrangement of biological cells and microscale objects plays an important role in many biological and colloidal studies such as microarrays, regenerative medicine, and tissue engineering. We have developed an acoustic-based tunable patterning technique that can control the cell pattern with the tunability of up to 72% [2]. This acoustic-based tunable patterning technique has the advantages of wide tunability, non-invasiveness, and ease of integration to lab-on-a-chip systems, and shall be valuable in many biological and tissue endingeering studies such as investigation of cell-cell interactions. Due to its significance, this work was selected as cover image at the journal Lab on a Chip.

8.Xiaoyun Ding, et al., Standing Surface Acoustic Wave (SSAW) Based Multichannel Cell Sorting, Lab on a Chip, Vol.12, pp. 4228–4231, 2012. Cell sorting is essential for many fundamental cell studies, cancer research, clinical medicine, and transplantation immunology. We developed an acoustic-based method that can precisely sort cell into five separate outlets of cells (Figure to the right), rendering it particularly desirable for multi-type cell sorting. Our device requires small sample volumes (~100 μl), making it an ideal tool for research labs and point-of-care diagnostics. Furthermore, it can be conveniently integrated with a small power supply, a fluorescent detection module, and a high-speed electrical feedback module to function as a fully integrated, portable, inexpensive, multi-color, miniature fluorescence-activated cell sorting (μFACS) system.

[Y. J. Liu, X. Ding, et al. Advanced Materials, Vol. 23, pp. 1656-1659, 2011. (featured as front cover image) ]

A surface acoustic wave (SAW)-driven light shutter is demonstrated using poly­mer-dispersed liquid crystals (PDLCs). Our experiments show that a PDLC film switches from a non-transparent state to a transparent state when subjected to a SAW. The working mechanism is analyzed theoretically and the acousto-optic properties of the PDLC film are characterized. This swit­ching behavior results from the acoustic streaming-induced realignment of liquid crystal (LC) molecules as well as SAW-induced thermal diffusion. Such a device shows an excellent performance in terms of imaging quality and optical contrast, which is important for display applications and smart windows.

• Rustum and Della Roy Innovation in Materials Research Award, Pennsylvania State University (2013)
• JALA Top Ten Breakthroughs of the Year Award, Journal of Laboratory Automation (2013)
• The Baxter Young investigator Award, USA(2012)
• Student Paper Competition Award,(7 out of 1200 worldwide) 2012 IEEE International Ultrasonics Symposium, Dresden, Germany(2012)
• Student Travel Award, 2012 IEEE International Ultrasonics Symposium, Dresden, Germany (2012)

• First place at Penn State ESM Today Graduate Research Symposium (Highest), The Pennsylvania State University (2012)ESM Today2012
• Innovation Award at Penn State ESM Today Graduate Research Symposium (Highest), The Pennsylvania State University (2011)ESM Today2011

National Science FoundationNational Institutes of Health Nature Methods Live Science Big Ten Science Lab Spaces One News Page gantdaily MSNBC R&D Medical News Today Nanowerk Science Daily Popular Science Online Journal Newswise domain-b Bio-Medicine Penn State Live Penn State Science Real Clear Science Sci Tech Update Phys Org UPI.com Softpedia ALN Magazine SciTechDaily Futurity DVICE Inside Science

• Xiaoyun Ding, and Tony Jun Huang, “HIGH-EFFICIENCY SEPARATION OF PARTICLES AND CELLS IN MICROFLUIDIC DEVICE USING SURFACE ACOUSTIC WAVE”, (U.S. Provisional Patent, PSU Inv. Disc. No.: 2012-3934)
  

• Xiaoyun Ding, and Tony Jun Huang, “MICROFLUIDIC MANIPULATION AND SORTING OF PARTICLES USING TUNABLE STANDING SURFACE ACOUSTIC WAVE”, (U.S. Provisional Patent, PSU Inv. Disc. No.: 2011-3882)
  

1. Xiaoyun Ding, Sz-Chin Steven Lin, Michael Ian Lapsley, Sixing Li, Xiang Guo, Chung Yu Keith Chan, I-Kao Chiang, J. Philip McCoy, and Tony Jun Huang, Standing surface acoustic wave (SSAW) based multichannel cell sorting, Lab On a Chip, Lab on a Chip, Vol.12, pp. 4228–4231, 2012.(featured as front cover image)[PDF]
2. Yan Jun Liu, Mengqian Lu, Xiaoyun Ding, Eunice S. P. Leong, Sz-Chin Steven Lin, Jinjie Shi, Jing Hua Teng, Lin Wang, Timothy J. Bunning, and Tony Jun Huang, Holographically formed, acoustically switchable gratings based on polymer-dispersed liquid crystals, Journal of Laboratory Automation, accepted, 2012.
3. Xiaoyun Ding, Sz-Chin Steven Lin, Brian Kiraly, Hongjun Yue, Sixing Li, Jinjie Shi, Stephen J. Benkovic, and Tony Jun Huang, On-Chip Manipulation of Single Microparticles, Cells, and Organisms Using Surface Acoustic Waves, Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 109, pp. 11105-11109, 2012. [PDF]
4. Xiaoyun Ding, Jinjie Shi, Sz-Chin Steven Lin, Shahrzad Yazdi, Brian Kiraly, and Tony Jun Huang, Tunable Patterning of Microparticles and Cells using Standing Surface Acoustic Waves, Lab on a Chip, Vol. 12, pp. 2491-2497, 2012. (featured as back cover image) [PDF]
5. Yan Jun Liu, Xiaoyun Ding, Sz-Chin Steven Lin, Jinjie Shi, I-Kao Chiang, and Tony Jun Huang, Surface Acoustic Wave Driven Light Shutters Using Polymer-Dispersed Liquid Crystals, Advanced Materials, Vol. 23, pp. 1656-1659, 2011. (featured as front cover image) [PDF]
6. Jinjie Shi, Shahrzad Yazdi, Sz-Chin Steven Lin, Xiaoyun Ding, I-Kao Chiang, Kendra Sharp, and Tony Jun Huang, Three-Dimensional Continuous Particle Focusing in a Microfluidic Channel via Standing Surface Acoustic Waves (SSAW), Lab on a Chip, Vol. 11, pp. 2319-2324, 2011. (featured as front cover image) [PDF]
7. Michael Ian Lapsley, I-Kao Chiang, Yue Bing Zheng, Xiaoyun Ding, Xiaole Mao, and Tony Jun Huang, A Single-Layer, Planar, Optofluidic Mach-Zehnder Interferometer for Label-Free Detection, Lab on a Chip, Vol. 11, pp. 1795–1800, 2011.[PDF]
8. J Tang, X Ding, F Geng, X Sun, L Luo, Wafer-level multilayer integration of RF passives with thick BCB/metal interlayer connection in silicon-based SiP, Microsystem Technologies, 1-8, 2012.
9. Xiaoyun Ding, Fei Geng, and Le Luo, Process development in metal/BCB multilayer interconnections of MMCM with embedded chip in Si substrate, Microelectronic Engineering, 86 (3), 335-339, 2009.
10. Xiaoyun Ding, Fei Geng, and Le Luo, Wideband vertical transitions for multilayer BCB‐based MCM, Microwave and Optical Technology Letters, 51 (6), 1584-1587, 2009.
11. Fei Geng, Xiaoyun Ding, Gaowei Xu, and Le Luo,A wafer-scale packaging structure with monolithic microwave integrated circuits and passives embedded in a silicon substrate for multichip modules for radio frequency applications, Journal of Micromechanics and Microengineering , 19, 105011, 2009.
12. Fei Geng , Xiaoyun Ding, Gaowei Xu ,and Luo Le , A wafer-level 3D packaging structure with Benzocyclobutene as a dielectric for multichip module fabrication, Journal of Semiconductors, 30, 106003, 2009.
    

• Xiaoyun Ding, and Tony Huang, “Acoustic tweezers: manipulating microparticles, cells, and organisms using standing surface acoustic waves (SSAW)” IEEE IUS Dresden, Germany, 2012. (Invited Talk)
• Xiaoyun Ding, Sz-Chin Steven Lin, Sixing Li, Lin Wang, Tony Jun Huang, “Manipulating Single Particles, Cells, and Organisms Using Standing Surface Acoustic waves,” MicroTAS Okinawa, Japan, 2012. (Oral Presentation)
• Xiaoyun Ding, Tony Jun Huang., “Size-dependent high-efficiency separation of particle/cell in microfluidics using tilted interdigital transducer,” IEEE IUS Dresden, Germany, 2012. (Student Paper Competition Award)
• Xiaoyun Ding, Sz-Chin Steven Lin, Sixing Li, Lin Wang, Tony Jun Huang, “Single cell manipulation via standing surface acoustic wave based tunnable acoustophoresis,” BMES Atlanta, GA, 2012. (Oral Presentation)
• Xiaoyun Ding, Sz-Chin Steven Lin, Lin Wang, Tony Jun Huang, “Multichannel cell sorting in microfluidics using chirped interdigital transducer”, IEEE IUS Dresden, Germany, 2012. (Oral Presentation)
• Xiaoyun Ding,Jinjie Shi, S.-C. Steven Lin, and Tony Jun Huang. “ACOUSTIC TWEEZERS: ACHIEVING QUASI-DYNAMIC MICROPARTCILE PATTERNING USING TUNABLE SURFACE ACOUSTIC WAVES”, the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducer’11) (Beijing, China, June, 2011).
• Yan Jun Liu, Xiaoyun Ding, Sz-Chin Steven Lin, Jinjie Shi, and Tony Jun Huang. “POLYMER-DISPERSED LIQUID CRYSTALS LIGHT SHUTTER DRIVEN BY SURFACE ACOUSTIC WAVE”, the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducer’11) (Beijing, China, June, 2011).

• 2012 Baxter Healthcare Corporation, Deerfield, IL– “Acoustic tweezers”

• Biomedical Engineer Society (BMES)
• Institute of Electrical and Electronics Engineers (IEEE)

• Lab on a Chip