BioNEMS

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Overview | BioNEMS | Microacoustics/Nanoacoustics | Microfluidics/Nanofluidics | Molecular Mechanics | Optofluidics | Plasmonics

We are devoted to the development of micro/nano sensors, actuators, and integrated systems that can detect and manipulate biological species with unprecedented speed, precision and manner. These Bio-NEMS devices will bridge the interface between modern molecular biology and nanotechnology.

Figure 1 shows an interferometrically created nanoporous polymeric structure as a platform for biosensing, humidity sensing, and drug delivery applications. Aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings was fabricated by combining holographic interference patterning and APTES-functionalization of pre-polymer syrup. The successful detection of multiple biomolecules indicates that our functionalized nanoporous polymeric gratings can act as biosensing platforms which are label-free, inexpensive, and applicable as high-throughput assays. Figure 2 shows SEM images of metal and semiconductor nanostructures used in biosensing applications.

Figure 1: SEM image of a nanoporous polymeric grating.	Figure 2: SEM images of metal and semiconductor nanostructures for biosensing.

1. Jinjie Shi, Vincent K. S. Hsiao, Thomas R. Walker, Tony Jun Huang, Humidity Sensing Based on Nanoporous Polymeric Photonic Crystals, Sensors and Actuators B: Chemical, Vol. 129, pp. 391-396, 2008. [PDF]
2. Yuebing Zheng, Bala Krishna Juluri, Xiaole Mao, Thomas R. Walker, Tony Jun Huang, Systematic Investigation of Localized Surface Plasmon Resonance of Long-Range Ordered Au Nanodisk Arrays, Journal of Applied Physics, Vol. 103, 014308, 2008. [PDF]
3. Vincent K. S. Hsiao, John R. Waldeisen, Yuebing Zheng, Pamela F. Lloyd, Timothy J. Bunning, Tony Jun Huang, Aminopropyltriethoxysilane (APTES)-Functionalized Nanoporous Polymeric Gratings: Fabrication and Application in Biosensing, Journal of Materials Chemistry, Vol. 17, pp. 4896-4901, 2007. [PDF]
4. Tony Jun Huang, Minghsun Liu, Linda D. Knight, Wayne W. Grody, Jeff F. Miller, Chih-Ming Ho, An Electrochemical Detection Scheme for Identification of Single-Nucleotide Polymorphisms Using Hairpin-Forming Probes, Nucleic Acids Research, Vol. 30, No. 12, e55, 2002. [PDF]