Applied Physics Letters
Dr. Melik Demirel, Associate Professor in Engineering Science and Mechanics, was highlighted on the cover of August 15 Applied Physics Letters publication. Demirel, along with three other collaborators demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. They provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. Furthermore, they quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model.